Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

The identification of effectors of retinal cell fate determination through single cell transcriptomics

Single Cell Transcriptomics and Flow Cytometry Reveal Disease- associated Fibroblast Subsets in Rheumatoid Arthritis

Single Cell Transcriptomics and Flow Cytometry Reveal Diseaseassociated Fibroblast Subsets in Rheumatoid Arthritis Fumitaka Mizoguchi, Kamil Slowikowski, Jennifer L Marshall, Kevin Wei, Deepak A Rao, Sook Kyung Chang, Hung N Nguyen, Erika H Noss, Jason D Turner, Brandon E Earp, Philip E Blazar, John Wright, Barry P Simmons, Laura T Donlin, George D Kalliolias, Susan M Goodman, Vivian P Bykerk, ...

Moore's Law in Single Cell Transcriptomics

The ability to measure the transcriptomes of single cells has only been feasible for a few years, and is becoming an extremely popular assay. While many types of analysis and questions can be answered using single cell RNA-sequencing, a central focus is the ability to survey the diversity of cell types within a sample. Unbiased and reproducible cataloging of distinct cell types requires large n...

Single Cell Transcriptomics: Methods and Applications

Traditionally, gene expression measurements were performed on "bulk" samples containing populations of thousands of cells. Recent advances in genomic technology have made it possible to measure gene expression in hundreds of individual cells at a time. As a result, cellular properties that were previously masked in "bulk" measurements can now be observed directly. In this review, we will survey...

Single-cell transcriptomics for microbial eukaryotes

One of the greatest hindrances to a comprehensive understanding of microbial genomics, cell biology, ecology, and evolution is that most microbial life is not in culture. Solutions to this problem have mainly focused on whole-community surveys like metagenomics, but these analyses inevitably loose information and present particular challenges for eukaryotes, which are relatively rare and posses...